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Speciality Services

DLCO

DLCO


Diffusing Capacity for Carbon Monoxide

This test provides information about the rate of oxygen transfer from the lung to the pulmonary capillary bed. This transfer occurs by a process of passive diffusion and is documented by using carbon monoxide, which is transferred by the same path, by binding with hemoglobin.

Principle

Gas exchange in the lungs across alveolar- capillary interface depends on its structural and functional properties.

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Structural properties

Lung gas volume; path length for diffusion in gas phase; thickness & area of the alveolar capillary membrane; effects of airway closure; and blood volume of the capillaries that are supplying the ventilated alveoli.

Functional properties

Absolute levels of ventilation & perfusion; their distribution relative to each other; alveolar gas composition; membrane diffusion characteristics; hemoglobin (Hb) concentration & its binding properties in alveolar capillaries; and gas tensions in blood where gas exchange is taking place.

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